Description
Tesofensine is a potent triple monoamine reuptake inhibitor, meaning it increases the levels of serotonin, dopamine, and norepinephrine in the brain. It was initially developed for the treatment of neurological disorders but was found to have a significant effect on weight loss. Tesofensine works by suppressing appetite and increasing metabolism, leading to a reduction in body weight.
Benefits:
- Significant Weight Loss: Clinical trials have shown that tesofensine can produce substantial weight loss. Astrup et al. (2008) reported that the 0.5mg dose resulted in an average weight loss of 11-13% of body weight over a six-month period in a randomized, double-blind, placebo-controlled trial.
- Appetite Suppression: It is a powerful appetite suppressant, helping to reduce calorie intake.
- Improved Metabolic Parameters: Tesofensine has been shown to improve various metabolic markers, including insulin sensitivity and lipid profiles.
Recommended Dosage: The most effective and well-tolerated dosage in clinical trials was 0.5 mg (500 mcg) per day. The 60-tablet package provides a two-month supply at this dosage.
Recommended Stacks:
- Performance & Body Composition Stack: For a comprehensive approach to fat loss, Tesofensine can be stacked with MOTS-C and Ipamorelin.
